Sulforaphane reduces adipose tissue fibrosis via promoting M2 macrophages polarization in HFD fed-mice

文献类型： 外文期刊

第一作者： Zhang, Zhenzhen

作者： Zhang, Zhenzhen;Chen, Huali;Pan, Cheng;Li, Rui;Zhao, Wangsheng;Zhang, Zhenzhen;Song, Tianzeng

作者机构：

关键词： Adipose tissue fibrosis; Obesity; Sulforaphane; Macrophages polarization; Nuclear factor E2-related factor 2; Metabolic disorders

期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH （ 影响因子：5.1； 五年影响因子：5.3 ）

ISSN： 0167-4889

年卷期： 2024 年 1871 卷 2 期

页码：

收录情况： SCI

摘要： Adipose tissue fibrosis has been identified as a novel contributor to the pathomechanism of obesity associated metabolic disorders. Sulforaphane (SFN) has been shown to have an anti-obesity effect. However, the impact of SFN on adipose tissue fibrosis is still not well understood. In this study, obese mice induced by high-fat diets (HFD) were used to examine the effects of SFN on adipose tissue fibrosis. According to the current findings, SFN dramatically enhanced glucose tolerance and decreased body weight in diet-induced-obesity (DIO) mice. Additionally, SFN therapy significantly reduced extracellular matrix (ECM) deposition and altered the expression of genes related to fibrosis. Furthermore, SFN also reduced inflammation and promoted macrophages polarization towards to M2 phenotype in adipose tissue, which protected adipose tissue from fibrosis. Notably, SFNmediated nuclear factor E2-related factor 2 (Nrf2) activation was crucial in decreasing adipose tissue fibrosis. These results implied that SFN had favorable benefits in adipose tissue fibrosis, which consequently ameliorates obesity-related metabolic problems. Our research provides new treatment strategies for obesity and associated metabolic disorders.

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