A natural allele of proteasome maturation factor improves rice resistance to multiple pathogens

文献类型： 外文期刊

第一作者： Hu, Xiao-Hong

作者： Hu, Xiao-Hong;Shen, Shuai;Wu, Jin-Long;Liu, Jie;Wang, He;He, Jia-Xue;Yao, Zong-Lin;Bai, Yi-Fei;Zhang, Xin;Zhu, Yong;Li, Guo-Bang;Zhao, Jing-Hao;Xu, Jie;Ji, Yun-Peng;Li, De-Qiang;Pu, Mei;Zhao, Zhi-Xue;Zhou, Shi-Xin;Zhang, Ji-Wei;Huang, Yan-Yan;Li, Yan;Lu, Yanli;Huang, Fu;Wang, Wen-Ming;Fan, Jing;You, Xiaoman;Ning, Yuese;Xu, Jie;Lu, Yanli;Huang, Fu

作者机构：

期刊名称：NATURE PLANTS （ 影响因子：18.0； 五年影响因子：18.6 ）

ISSN： 2055-026X

年卷期： 2023 年 9 卷 2 期

页码：

收录情况： SCI

摘要： Crops with broad-spectrum resistance to multiple diseases are highly desirable in agricultural production. This study reports a natural gene variant that produces a proteasome maturation factor and improves rice resistance to four notorious pathogens. Crops with broad-spectrum resistance loci are highly desirable in agricultural production because these loci often confer resistance to most races of a pathogen or multiple pathogen species. Here we discover a natural allele of proteasome maturation factor in rice, UMP1(R2115), that confers broad-spectrum resistance to Magnaporthe oryzae, Rhizoctonia solani, Ustilaginoidea virens and Xanthomonas oryzae pv. oryzae. Mechanistically, this allele increases proteasome abundance and activity to promote the degradation of reactive oxygen species-scavenging enzymes including peroxidase and catalase upon pathogen infection, leading to elevation of H2O2 accumulation for defence. In contrast, inhibition of proteasome function or overexpression of peroxidase/catalase-encoding genes compromises UMP1(R2115)-mediated resistance. More importantly, introduction of UMP1(R2115) into a disease-susceptible rice variety does not penalize grain yield while promoting disease resistance. Our work thus uncovers a broad-spectrum resistance pathway integrating de-repression of plant immunity and provides a valuable genetic resource for breeding high-yield rice with multi-disease resistance.

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