Genome-Wide Association Study of Arsenic Accumulation in Polished Rice

文献类型： 外文期刊

第一作者： Dong, Zheng

作者： Dong, Zheng;Guo, Liang;Li, Xiaoxiang;Li, Yongchao;Liu, Wenqiang;Chen, Zuwu;Liu, Licheng;Liu, Zhixi;Guo, Yujing;Pan, Xiaowu;Dong, Zheng;Guo, Liang;Li, Xiaoxiang;Li, Yongchao;Liu, Wenqiang;Chen, Zuwu;Liu, Licheng;Liu, Zhixi;Guo, Yujing;Pan, Xiaowu

作者机构：

关键词： arsenic; GWAS; MYB transcription factor; polished rice

期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）

ISSN：

年卷期： 2023 年 14 卷 12 期

页码：

收录情况： SCI

摘要： The accumulation of arsenic (As) in rice poses a significant threat to food safety and human health. Breeding rice varieties with low As accumulation is an effective strategy for mitigating the health risks associated with arsenic-contaminated rice. However, the genetic mechanisms underlying As accumulation in rice grains remain incompletely understood. We evaluated the As accumulation capacity of 313 diverse rice accessions grown in As-contaminated soils with varying As concentrations. Six rice lines with low As accumulation were identified. Additionally, a genome-wide association studies (GWAS) analysis identified 5 QTLs significantly associated with As accumulation, with qAs4 being detected in both of the experimental years. Expression analysis demonstrated that the expression of LOC_Os04g50680, which encodes an MYB transcription factor, was up-regulated in the low-As-accumulation accessions compared to the high-As-accumulation accessions after As treatment. Therefore, LOC_Os04g50680 was selected as a candidate gene for qAs4. These findings provide insights for exploiting new functional genes associated with As accumulation and facilitating the development of low-As-accumulation rice varieties through marker-assisted breeding.

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