Antimicrobial Lobophorins from Endophytic Strain Streptomyces sp. R6 Obtained from Azadirachta indica

文献类型： 外文期刊

第一作者： Chen, Xinyuan

作者： Chen, Xinyuan;Du, Ying;Ma, Yunlong;Liu, Peibin;Chen, Yan

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关键词： antimicrobial activity; Lobophorins; Polyketides; plant disease; Streptomyces sp. R6

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：5.0 ）

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年卷期： 2025 年 30 卷 3 期

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收录情况： SCI

摘要： Endophytic bacteria are an important source for developing antimicrobial substances. With the aim to find eco-friendly antimicrobial agents from natural sources, Streptomyces sp. R6 was isolated from Azadirachta indica. After that, a new spirotetronate natural product, lobophorin S (compound 2), together with lobophorin H8 (compound 1) and a known macrolide compound divergolide C (compound 3) were isolated from the cultural solution of strain R6. These compounds mark the first isolation of marine-derived microbial natural products known as lobophorins (LOBs) from endophytic bacteria. The structures of these three compounds were identified by extensive NMR and HRMS analyses. The antimicrobial activities of these three compounds against eight fungal and four bacterial phytopathogens were separately evaluated. Compound 1 demonstrated better antibacterial activity against Erwinia carotovora, Pseudomonas syringae pv. tomato, and P. syringae pv. lachrymans with MIC values of 3.91, 7.81, and 15.63 mu g/mL, respectively. Additionally, compounds 1-3 all showed antifungal activity against Botrytis cinerea, with the MIC values of 1.95, 7.81, and 15.63 mu g/mL, respectively. Notably, the in vivo antifungal effect of 1 against B. cinerea was up to 78.51 +/- 3.80% at 1.95 mu g/mL, significantly surpassing polyoxin B (70.70 +/- 3.81%). These results highlight the potential of lobophorins as promising lead compounds for the development of new, sustainable agents to control plant diseases.

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