Juvenile hormone inhibits lipogenesis of Spodoptera exigua to response to Bacillus thuringiensis GS57 infection

文献类型： 外文期刊

第一作者： Gao, Bo

作者： Gao, Bo;Ji, Yujie;Yan, Yitong;Zhang, Lu;Wu, Han;Xie, Yifan;Shi, Qiuyu;Wang, Yao;Guo, Wei;Ji, Yujie;Zhao, Dan

作者机构：

关键词： Bacillus thuringiensis; Lipid metabolism; Fatty acid synthases; Juvenile hormone; Triglyceride

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.0； 五年影响因子：4.5 ）

ISSN： 0048-3575

年卷期： 2024 年 205 卷

页码：

收录情况： SCI

摘要： The application of Bacillus thuringiensis (Bt) has brought environmental benefits and delayed resistance development of pests. Most studies focus on the Bt insecticidal activity against pests, however, the molecular mechanism of Bt on impairing the growth and development of Spodoptera exigua remains unknown. Here, we show that juvenile hormone (JH) inhibits the lipogenesis mediated by fatty acid synthases (Fas) of S. exigua in response to Bt infection. The weight and lipid accumulation of S. exigua larvae post Bt infection were less than those of larvae without Bt infection. We further demonstrated that Bt infection causes the JH titer with a significant increase, which downregulates the expression of lipogenesis-related genes, SeFas3, SeFas4, and SeFas5, resulting in the delayed development of S. exigua larvae. In addition, the expression levels of SeFas genes were regulated by SeACC, indicating that SeFas genes were modulated by multiple pathways. Our findings reveal that novel insights into the molecular mechanisms underlying the impaired development caused by Bt infection which can inform the development of strategies for the sustainable pest control in the future.

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