Genome-wide selective sweep analysis of plateau-type Tibetan and Zhashijia Sheep: Insights into adaptation, growth, and meat production traits

文献类型： 外文期刊

第一作者： Liu, Dehui

作者： Liu, Dehui;Li, Xue;Han, Buying;Wang, Song;Tian, Fei;Liu, Sijia;Zhao, Kai;Tian, Dehong;Liu, Dehui;Wang, Song;Zhao, Jincai;Wang, Lei;Pei, Quanbang;Ren, Qianben;Zhang, Wenkui;Liu, Dehui;Sun, De;Bao, Guoxiang

作者机构：

关键词： Genome-wide association; High-altitude adaptation; Selective sweep; Candidate genes; Plateau-type Tibetan sheep; Zhashijia sheep

期刊名称：SMALL RUMINANT RESEARCH （ 影响因子：1.4； 五年影响因子：1.7 ）

ISSN： 0921-4488

年卷期： 2025 年 252 卷

页码：

收录情况： SCI

摘要： Qinghai is renowned as "China's capital of Tibetan sheep," with plateau-type Tibetan sheep and Zhashijia sheep being exceptional breeds in the province. However, limited knowledge exists regarding the genetic characteristics or variations underlying their economically essential traits. Therefore, the present study was carried out on plateau-type Tibetan and Zhashijia sheep and aimed to identify the candidate genes regulating the differences in production performance between them by genome-wide selective sweep analysis and, ultimately, by combined analyses of two methods (Fst and Pi, Pi and Tajima's D). This study identified genes associated with plateau acclimatization, growth and development, body size, and meat quality through Fst, Pi, and Tajima's D. These genes include HBB, HBE1, GPX1, the HOX gene family, SIRT3, MRAP2, MMAB, BMP4, NCAM2, PCCA, MRPS6, P4HTM, and PLAAT3. Enrichment analyses indicated significant enrichment in key pathways, including amino sugar and nucleotide sugar metabolism, arachidonic acid metabolism, Carbon metabolism, and ribosome function. The findings provided valuable insights for breeding programs to improve growth performance in Tibetan sheep.

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