文献类型： 外文期刊
第一作者： Zhang, Shunfen
作者： Zhang, Shunfen;Zhong, Ruqing;Tang, Shanlong;Chen, Liang;Zhang, Hongfu;Zhang, Shunfen
作者机构：
关键词： IBD; Th17/Treg balance; Calorie level; Time-limited eating; Caloric restriction
期刊名称：PHARMACOLOGICAL RESEARCH （ 影响因子：9.3； 五年影响因子：8.8 ）
ISSN： 1043-6618
年卷期： 2024 年 203 卷
页码：
收录情况： SCI
摘要： Inflammatory bowel disease (IBD) is a long-lasting and inflammatory autoimmune condition affecting the gastrointestinal tract, impacting millions of individuals globally. The balance between T helper 17 (Th17) cells and regulatory T cells (Tregs) is pivotal in the pathogenesis and progression of IBD. This review summarizes the pivotal role of Th17/Treg balance in maintaining intestinal homeostasis, elucidating how its dysregulation contributes to the development and exacerbation of IBD. It comprehensively synthesizes the current understanding of how dietary factors regulate the metabolic pathways influencing Th17 and Treg cell differentiation and function. Additionally, this review presents evidence from the literature on the potential of dietary regimens to regulate the Th17/Treg balance as a strategy for the management of IBD. By exploring the intersection between diet, metabolic regulation, and Th17/Treg balance, the review reveals innovative therapeutic approaches for IBD treatment, offering a promising perspective for future research and clinical practice.
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