文献类型： 外文期刊
第一作者： Zhong, Haoran
作者： Zhong, Haoran;Ren, Yuqi;Dong, Bowen;Zhu, Danlin;Li, Hao;Lu, Ke;Fu, Zhiqiang;Liu, Jinming;Jin, Yamei;Zhong, Haoran;Ren, Yuqi;Dong, Bowen;Zhu, Danlin;Li, Hao;Lu, Ke;Fu, Zhiqiang;Liu, Jinming;Jin, Yamei;Hou, Ling;Gu, Shaopeng;Qin, Fanglin
作者机构：
关键词： Schistosoma japonicum; annexin A13; development; immune protection; host-parasite interaction
期刊名称：VETERINARY RESEARCH （ 影响因子：4.4； 五年影响因子：4.3 ）
ISSN： 0928-4249
年卷期： 2023 年 54 卷 1 期
页码：
收录情况： SCI
摘要： Schistosomiasis is a neglected tropical disease that affects humans and animals in tropical and subtropical regions worldwide. Schistosome eggs are responsible for the pathogenesis and transmission of schistosomiasis, thus reducing egg production is vital for prevention and control of schistosomiasis. However, the mechanisms underlying schistosome reproduction remain unclear. Annexin proteins (ANXs) are involved in the physiological and pathological functions of schistosomes, but the specific regulatory mechanisms and roles of ANX A13 in the development of Schistosoma japonicum and host-parasite interactions remain poorly understood. Therefore, in this study, the expression profiles of SjANX A13 at different life cycle stages of S. japonicum were assessed using quantitative PCR. In addition, the expression profiles of the homolog in S. mansoni were analyzed in reference to public datasets. The results of RNA interference showed that knockdown of SjANX A13 significantly affected the development and egg production of female worms in vivo. The results of an immune protection assay showed that recombinant SjANX A13 increased production of immunoglobulin G-specific antibodies. Finally, co-culture of S. japonicum exosomes with LX-2 cells using a transwell system demonstrated that SjANX A13 is involved in host-parasite interactions via exosomes. Collectively, these results will help to clarify the roles of SjANX A13 in the development of S. japonicum and host-parasite interactions as a potential vaccine candidate.
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