Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model
文献类型： 外文期刊
第一作者： Huang, Juqing
作者： Huang, Juqing;Lai, Gongti;Guan, Xuefang;Chen, Bingyan;Wang, Qi;Huang, Juqing;Lai, Gongti;Guan, Xuefang;Chen, Bingyan;Wang, Qi;Huang, Juqing;Lai, Gongti;Guan, Xuefang;Chen, Bingyan;Wang, Qi;Cai, Xiaohui;Liu, Xiaoyan
作者机构：
关键词： colostrum; Obesity; Gut microbiota; Intestinal immunity
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.0； 五年影响因子：4.9 ）
ISSN： 1756-4646
年卷期： 2025 年 125 卷
页码：
收录情况： SCI
摘要： This study evaluated the effects of L. fermentum B153 (derived from human colostrum) on intestinal immunity and gut microbiota in a high-fat diet-induced obese mouse model. The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased the villus height to crypt depth (V/C) ratio in both the ileum and jejunum of obese mice. Intestinal inflammation induced by the high-fat diet was alleviated by L. fermentum B153, as evidenced by the upregulation of E-cadherin and IL-6 mRNA expression, alongside the downregulation of TNF-alpha mRNA expression. Furthermore, L. fermentum B153 significantly altered the gut microbiome composition of obese mice, characterized by a substantial increase in the relative abundance of the potentially beneficial genus Akkermansia and a notable decrease in the richness of potentially harmful bacteria (e.g., Lachnoclostridium, Romboutsia and Dubosiella). In conclusion, L. fermentum B153 positively modulated intestinal immunity and gut microbiota in obese mice.
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