Highly Pathogenic Avian Influenza Virus (H5N1) Clade 2.3.4.4b Introduced by Wild Birds, China, 2021

文献类型： 外文期刊

第一作者： Tian, Jingman

作者： Tian, Jingman;Bai, Xiaoli;Li, Minghui;Zeng, Xianying;Song, Xingdong;Zhao, Zhiguo;Tian, Guobin;Liu, Liling;Guan, Yuntao;Li, Yanbing;Chen, Hualan;Xu, Jia;Li, Peng;Wang, Miao;Li, Yanbing;Chen, Hualan

作者机构：

期刊名称：EMERGING INFECTIOUS DISEASES （ 影响因子：11.8； 五年影响因子：8.7 ）

ISSN： 1080-6040

年卷期： 2023 年 29 卷 7 期

页码：

收录情况： SCI

摘要： Highly pathogenic avian influenza (HPAI) subtype H5N1 clade 2.3.4.4b virus has spread globally, causing un-precedented large-scale avian influenza outbreaks since 2020. In 2021, we isolated 17 highly pathogenic avian influenza H5N1 viruses from wild birds in China. To de-termine virus origin, we genetically analyzed 1,529 clade 2.3.4.4b H5N1 viruses reported globally since October 2020 and found that they formed 35 genotypes. The 17 viruses belonged to genotypes G07, which originated from eastern Asia, and G10, which originated from Rus-sia. The viruses were moderately pathogenic in mice but were highly lethal in ducks. The viruses were in the same antigenic cluster as the current vaccine strain (H5-Re14) used in China. In chickens, the H5/H7 trivalent vaccine provided complete protection against clade 2.3.4.4b H5N1 virus challenge. Our data indicate that vaccination is an effective strategy for preventing and controlling the globally prevalent clade 2.3.4.4b H5N1 virus.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序