A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

文献类型： 外文期刊

第一作者： Zhao, Yinghua

作者： Zhao, Yinghua;Sui, Liyan;Wang, Zedong;Tan, Guangyun;Liu, Quan;Wu, Ping;Hou, Zhijun;Liu, Quan;Wang, Wenfang;Wang, Guoqing;Yu, Yang;Liu, Quan;Liu, Quan

作者机构：

期刊名称：SIGNAL TRANSDUCTION AND TARGETED THERAPY （ 影响因子：18.187； 五年影响因子：21.177 ）

ISSN： 2095-9907

年卷期： 2021 年 6 卷 1 期

页码：

收录情况： SCI

摘要： The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of ongoing global pandemic of COVID-19, may trigger immunosuppression in the early stage and overactive immune response in the late stage of infection; However, the underlying mechanisms are not well understood. Here we demonstrated that the SARS-CoV-2 nucleocapsid (N) protein dually regulated innate immune responses, i.e., the low-dose N protein suppressed type I interferon (IFN-I) signaling and inflammatory cytokines, whereas high-dose N protein promoted IFN-I signaling and inflammatory cytokines. Mechanistically, the SARS-CoV-2 N protein dually regulated the phosphorylation and nuclear translocation of IRF3, STAT1, and STAT2. Additionally, low-dose N protein combined with TRIM25 could suppress the ubiquitination and activation of retinoic acid-inducible gene I (RIG-I). Our findings revealed a regulatory mechanism of innate immune responses by the SARS-CoV-2 N protein, which would contribute to understanding the pathogenesis of SARS-CoV-2 and other SARS-like coronaviruses, and development of more effective strategies for controlling COVID-19.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序