Algal Oil Rich in Docosahexaenoic Acid Alleviates Intestinal Inflammation Induced by Antibiotics Associated with the Modulation of the Gut Microbiome and Metabolome

文献类型： 外文期刊

第一作者： Yang, Chen

作者： Yang, Chen;Xu, Zhenxia;Deng, Qianchun;Chen, Wenchao;Huang, Fenghong;Qiao, Zhixian;Wang, Xu

作者机构：

关键词： algal oil; docosahexaenoic acid (DHA); antibiotics; gut microbiota; untargeted metabolome

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2021 年 69 卷 32 期

页码：

收录情况： SCI

摘要： In this study, the effect of algal oil rich in docosahexaenoic acid on the mucosal injury with gut microbiota disorders caused by ceftriaxone sodium (CS) was evaluated. The results showed that algal oil treatment (500 mg kg(-1) day(-1)) significantly reduced the levels of pro-inflammatory cytokines, including interleukin 6, interleukin 1 beta, and tumor necrosis factor alpha, in the colon. Algal oil restored the CS-induced gut microbiota dysbiosis by elevating some short-chain-fatty-acid-producing bacteria, e.g., Ruminococcus and Blautia. The CS-induced metabolic disorder was also regulated by algal oil, which was characterized by the modulations of tryptophan metabolism, phospholipid metabolism, and bile acid metabolism. Our results suggested that supplementation of algal oil could alleviate inflammation and promote mucosal healing, which could be a functional food ingredient to protect aganist antibiotic-induced alteration of gut microbiota and metabolic dysbiosis.

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