Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease

文献类型： 外文期刊

第一作者： Li, Jinling

作者： Li, Jinling;Zhang, Xin;Li, Jinling;Luo, Ting;Wang, Dou;Yang, Guiling;Zhang, Xin;Zhao, Yao;Jin, Yuanxiang;Yang, Guiling;Jin, Yuanxiang

作者机构：

关键词： Plant-derived extracellular vesicles; Inflammatory bowel disease; Immune response; Intestinal barrier; Gut microbiota

期刊名称：JOURNAL OF ADVANCED RESEARCH （ 影响因子：13.0； 五年影响因子：11.6 ）

ISSN： 2090-1232

年卷期： 2025 年 68 卷

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收录情况： SCI

摘要： Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies. Aim of review: This review summarizes the recent advances and potential mechanisms underlying PDEVs obtained from different sources to alleviate IBD. In addition, the review discusses the possible applications and challenges of PDEVs, providing a theoretical basis for exploring novel and practical therapeutic strategies for IBD. Key scientific concepts of review: In IBD, the crosstalk mechanism of PDEVs may regulate the intestinal microenvironment homeostasis, especially immune responses, the intestinal barrier, and the gut micro- biota. In addition, drug loading enhances the therapeutic potential of PDEVs, particularly regarding improved tissue targeting and stability. In the future, not only immunotherapy based on PDEVs may be an effective treatment for IBD, but also the intestinal barrier and intestinal microbiota will be a new direction for the treatment of IBD. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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