文献类型： 外文期刊
第一作者： Wang, Jinming
作者： Wang, Jinming;Chai, Yijun;Yang, Jifei;Ye, Yuxin;Luo, Jianxun;Yin, Hong;Guan, Guiquan;Wang, Jinming;Chai, Yijun;Yang, Jifei;Ye, Yuxin;Luo, Jianxun;Yin, Hong;Guan, Guiquan;Yin, Hong
作者机构：
关键词：
asexual development;
期刊名称：FASEB JOURNAL （ 影响因子：4.2； 五年影响因子：4.5 ）
ISSN： 0892-6638
年卷期： 2024 年 38 卷 20 期
页码：
收录情况： SCI
摘要： Babesia spp. are obligate intracellular parasites that invade host cells to complete their asexual development and transmission. Here, we identified a transcription factor AP2-M (BXIN_0799) in Babesia sp. Xinjiang (Bxj), a member of the Apicomplexan AP2 family, which regulates gene expression related to red blood cell (RBC) invasion and cell cycle progression. Our genome-wide analysis of (Cut-Tag) data shows that AP2-M specifically recognized DNA motifs in the promoters of target genes. AP2-M target genes included other AP2 gene family members and epigenetic markers, which could modulate gene expression involved in RBC invasion, merozoite morphology, and cell cycle phases, as indicated by RNA sequencing, proteomics, and single-cell RNA sequencing (scRNA-seq) data from an ap2-m gene disrupted strain (AP2-M (-)). We conclude that AP2-M appeared to contribute to the process of red blood cell invasion, maintain merozoite morphology, and cell cycle progression through GS and MS phases.
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