Dipylidium caninum draft genome-a new resource for comparative genomic and genetic explorations of flatworms

文献类型： 外文期刊

第一作者： Liu, Guo-Hua

作者： Liu, Guo-Hua;Wang, Shuai;Zhu, Xing-Quan;Liu, Guo-Hua;Fu, Yi-Tian;Korhonen, Pasi K.;Young, Neil D.;Wang, Tao;Koehler, Anson V.;Hofmann, Andreas;Chang, Bill C. H.;Gasser, Robin B.;Lu, Jiang;Li, Nan;Lin, Chu-Yu;Zhang, Hui;Xiangli, Lingzi;Lin, Lin;Liu, Wei-Min;Li, Nan;Li, Hua-Wei;Lu, Jiang;Li, Nan;Lin, Chu-Yu;Zhang, Hui;Xiangli, Lingzi;Lin, Lin;Liu, Wei-Min;Li, Nan;Li, Hua-Wei;Hofmann, Andreas;Zhu, Xing-Quan

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关键词： Cestode; Tapeworm; Dipylidium caninum; Nuclear genome; Comparative genomic and genetic analyses

期刊名称：GENOMICS （ 影响因子：5.736； 五年影响因子：4.939 ）

ISSN： 0888-7543

年卷期： 2021 年 113 卷 3 期

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收录情况： SCI

摘要： Here, we present a draft genome of the tapeworm Dipylidium caninum (family Dipylidiidae) and compare it with other cestode genomes. This draft genome of D. caninum is 110 Mb in size, has a repeat content of -13.4% and is predicted to encode -10,000 protein-coding genes. We inferred excretory/secretory molecules (representing the secretome), other key groups of proteins (including peptidases, kinases, phosphatases, GTPases, receptors, transporters and ion-channels) and predicted potential intervention targets for future evaluation. Using 144 shared single-copy orthologous sequences, we investigated the genetic relationships of cestodes for which nuclear genomes are available. This study provides first insights into the molecular biology of D. caninum and a new resource for comparative genomic and genetic explorations of this and other flatworms.

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