Traditional Chinese herbal formulas modulate inflammatory mediators, antioxidant enzyme levels, and ruminal microbiota composition in postpartum female Yaks

文献类型： 外文期刊

第一作者： Zhu, Yanbin

作者： Zhu, Yanbin;Cidan, Yangji;Wang, Hongzhuang;Basang, Wangdui;Wang, Jia;Ali, Munwar;Li, Kun;Zhang, Xiaojuan;Pubu, Panduo

作者机构：

关键词： Antioxidant; Rumen; 16S rRNA sequencing; Microbiome; Bos grunniens; Herbal

期刊名称：SCIENTIFIC REPORTS （ 影响因子：3.9； 五年影响因子：4.3 ）

ISSN： 2045-2322

年卷期： 2025 年 15 卷 1 期

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收录情况： SCI

摘要： Traditional Chinese Medicine (TCM) is an emerging area due to increased antimicrobial resistance (AMR). The objective of this research was to explore the antioxidant, and anti-inflammatory potential of three traditional Chinese herbal formulas (TCHFs), along with variations in rumen bacteria. In this study, forty postpartum (80 +/- 15) female yaks after the calves had weaned (PWFs) were divided into three experimental groups, which were offered basal feed with 5% (95% basal diet) TCHF1 (DE group), 5% TCHF2 (DF group) and 5% TCHF3 (DG group), and fourth, control group (DH group), fed only a basal diet for 30 days. Following blood and rumen fluid samples on the 15th and 30th day, ELISA testing was performed to check antioxidant enzyme levels and inflammatory mediators. The results indicated that TCHF2 significantly upregulated the interleukin-10 (IL-10) (p < 0.05). Additionally, 16 S rRNA sequencing results showed that TCHF2 significantly enhanced Firmicutes to Bacteroidetes ratio (F/B) at the phylum level. On day 15th, phylum Actinobacteria, SR1, Cyanobacteria, and Armatimonadetes were found to be significantly (p < 0.05) different, while, at the genus level, Butyrivibrio, CF231, YRC22, Moraxella, Clostridium, etc. were significantly different (p < 0.05). On day 30, phylum SR1, Armatimonadetes, Chlorobi, and genus Coprococcus, Oscillospira, Selenomonas, L7A_E11, Clostridium, etc. were found to be significantly different (p < 0.05). This study concluded that TCHF2 is the most effective one among all.

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