G-quadruplexes in genomes of viruses infecting eukaryotes or prokaryotes are under different selection pressures from hosts

文献类型： 外文期刊

第一作者： Li, Zhen

作者： Li, Zhen;Wei, Dengguo;Li, Zhen;Qian, Sheng Hu;Chen, Zhen-Xia;Wei, Dengguo;Li, Zhen;Qian, Sheng Hu;Chen, Zhen-Xia;Wei, Dengguo;Li, Zhen;Qian, Sheng Hu;Chen, Zhen-Xia;Wang, Fan;Yang, Guangfu;Wang, Fan;Yang, Guangfu;Mohamed, Hany, I;Chen, Zhen-Xia;Chen, Zhen-Xia;Chen, Zhen-Xia;Wei, Dengguo;Wei, Dengguo

作者机构：

关键词： G-quadruplex; Selection pressure; Database; Evolution

期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：5.723； 五年影响因子：5.755 ）

ISSN： 1673-8527

年卷期： 2022 年 49 卷 1 期

页码：

收录情况： SCI

摘要： G-quadruplexes in viral genomes can be applied as the targets of antiviral therapies, which has attracted wide interest. However, it is still not clear whether the pervasive number of such elements in the viral world is the result of natural selection for functionality. In this study, we identified putative quadruplex-forming sequences (PQSs) across the known viral genomes and analyzed the abundance, structural stability, and conservation of viral PQSs. A Viral Putative G-quadruplex Database (http://jsjds.hzau.edu.cn/MBPC/ ViPGD/index.php/home/index) was constructed to collect the details of each viral PQS, which provides guidance for selecting the desirable PQS. The PQS with two putative G-tetrads (G(2)-PQS) was significantly enriched in both eukaryotic viruses and prokaryotic viruses, whereas the PQSs with three putative G-tetrads (G(3)-PQS) were only enriched in eukaryotic viruses and depleted in prokaryotic viruses. The structural stability of PQSs in prokaryotic viruses was significantly lower than that in eukaryotic viruses. Conservation analysis showed that the G(2)-PQS, instead of G(3)-PQS, was highly conserved within the genus. This suggested that the G(2)-quadruplex might play an important role in viral biology, and the difference in the occurrence of G-quadruplex between eukaryotic viruses and prokaryotic viruses may result from the different selection pressures from hosts. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

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