Simultaneous Determination of 11 beta-Agonists in Human Urine Using High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Isotope Dilution
文献类型: 外文期刊
第一作者: Wang, Xiaoli
作者: Wang, Xiaoli;Wang, Shanshan;Yuan, Jinpeng;Zhao, Rusong;Guo, Tao
作者机构: Shandong Acad Sci, Anal & Test Ctr, Key Lab Appl Technol Sophisticated Analyt Instrum, Jinan 250014, Peoples R China;Shandong Acad Agr Sci, Shandong Rice Res Inst, Jinan 250010, Peoples R China
期刊名称:JOURNAL OF ANALYTICAL TOXICOLOGY ( 2020影响因子:3.367; 五年影响因子:3.21 )
ISSN: 0146-4760
年卷期: 2015 年 39 卷 3 期
收录情况: SCI
摘要: The misuse of beta-agonists constitutes a potential risk to public health and has been forbidden in many countries. In this study, we describe a method for specific, sensitive and rapid detection of beta-agonists in human urine. Urine samples were extracted with ethyl acetate, without any additional purification step, and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) with Clenbuterol-D9 and Salbuterol-D3 as internal standards. The intra-and interday precision values of the method were all <5.60% and the accuracy ranged from 94.5 to 109%. Extraction recovery for 11 beta-agonists varied from 66.7 to 108%. One UPLC-MS-MS analysis could be completed within 12 min and the limits of detection for 11 beta-agonists were 0.1 ng/mL in the experiment. beta-Agonists in human urines from 24 volunteers were analyzed by our validated method and 1.70 ng/mL salbutamol was detected in one volunteer. The application of UPLC-MS-MS method in beta-agonists detection of human urine will be helpful in veterinary control of beta-agonists and for studying the effect of beta-agonists on human health.
- 相关文献
作者其他论文 更多>>
-
Enhancing radiation-resistance and peroxidase-like activity of single-atom copper nanozyme via local coordination manipulation
作者:Wu, Jiabin;Li, Beibei;Ye, Chengliang;Wang, Dingsheng;Li, Yadong;Zhu, Xianyu;Chang, Qingchao;Xiang, Huandong;Liang, Yan;Zhao, Yuliang;Zhu, Xianyu;Chang, Qingchao;Xiang, Huandong;Liang, Yan;Zhao, Yuliang;Zhu, Xianyu;Li, Qiqiang;Li, Qun;Huang, Liang;Fu, Qiang;Wang, Bingxue;Fu, Qiang;Wang, Shanshan;Xiang, Huandong;Zhao, Yuliang;Li, Yadong;Li, Yadong
关键词:
-
A temperature-responsive mixed matrix membrane based on poly(ionic liquid)@poly(N-isopropylacrylaminde) microgels and polyvinylidene fluoride for the selective separation of citrus flavonoids
作者:Qin, Zongkui;Lei, Tian;Liu, Leilei;Wang, Shanshan;Liu, Leilei;Tan, Zhijian
关键词:Citrus flavonoids; Membrane separation; Temperature-responsive mixed matrix; membranes; Poly(ionic liquid)s; Bioactive compounds
-
Optimizing single-atom cerium nanozyme activity to function in a sequential catalytic system for colorimetric biosensing
作者:Chang, Qingchao;Zhang, Ruiting;Wang, Shanshan;Cheng, Zan;Jin, Maojun;Jin, Fen;Wang, Jing;Wu, Jiabin;Xu, Peng;Chang, Qingchao;Li, Xiaoke;Chang, Qingchao;Zhu, Xianyu;Xiang, Huandong;Wan, Yilong
关键词:Single-atom nanozyme; Lanthanide; Sequential catalytic system; Colorimetric biosensing; Organophosphorus pesticides
-
Deep learning based on the Vis-NIR two-dimensional spectroscopy for adulteration identification of beef and mutton
作者:Wang, Li;Li, Fei;Guo, Tao;Shi, Yanli;Li, Fadi;Liang, Jing;Xu, Hui;Hao, Shengyan;Xu, Hui
关键词:2DCOS; Vis-NIR; Adulterated beef and mutton; Deep learning
-
Exogenous Uniconazole Application Positively Regulates Carbon Metabolism under Drought Stress in Wheat Seedlings
作者:Jiang, Ying;Rong, Hao;Wang, Qiang;Lu, Yingchao;Li, Na;Li, Weiqiang;Li, Min;Xie, Tao;Wang, Shanshan;Zhao, Hong;Qian, Yumei;Cao, Yanyong;Cao, Yanyong;Qian, Yumei
关键词:wheat; uniconazole; carbon metabolism; gene expression; drought stress
-
Soil drought during the development of cotton ovule destroyed the antioxidant balance of cotton pistil to hinder the ovule formation
作者:Cheng, Mengdie;Wang, Zhanhan;Cao, Yuting;Zhang, Jipeng;Yu, Huilian;Wang, Shanshan;Zhou, Zhiguo;Hu, Wei;Zhang, Jipeng
关键词:antioxidant metabolism; cytological structure; drought; Gossypium hirsutum; ovule formation; pistil fertility
-
Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination
作者:Liang, Yu-Jie;Long, Ding-Xin;Wang, Hui-Ping;Wu, Yi-Jun;Liang, Yu-Jie;Long, Ding-Xin;Wang, Shanshan
关键词:Multiple-pesticide exposure; Subacute toxicity; Organophosphate; Pyrethroid; Metabolomics analysis