A multi-omics dataset of C57 BL/6J mice regulated function by feed with ε-polylysine

文献类型： 外文期刊

第一作者： Zhang, Xuelei

作者： Zhang, Xuelei;Cao, Yuxin;Wang, Songshan;Zhang, Yong;Wang, Jinrong;Hou, Zhenping;Wu, Duanqin

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期刊名称：SCIENTIFIC DATA （ 影响因子：6.9； 五年影响因子：8.7 ）

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年卷期： 2025 年 12 卷 1 期

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收录情况： SCI

摘要： The proteomic and metabolomic differences in mice fed epsilon-polylysine were detected by high-throughput sequencing and screening. The effects of epsilon-polylysine on the proteome and metabolomics of C57 BL/6 J mice were studied. DIA proteome sequencing and liquid chromatography-mass spectrometry (LC-MS) were used to compare epsilon-polylysine-modified mouse proteome and metabolome. In this study, we analyzed the regulatory effects of epsilon-polysine on glycerophospholipid metabolism, glutathione metabolism, and ABC transporters pathways. The sequencing data and LC-MS/MS raw data of samples are stored in MetaboLights and ProteomeXchange databases for efficient reuse and to explore the differences in metabolism and protein expression among mice fed with different levels of epsilon-polylysine, aiming to screen for critical proteins and differential metabolites in valuable regulatory pathways.

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