Melatonin promotes the proliferation of dermal papilla cells in cashmere goats via activation of chi-let-7d-5p/WNT2 axis

文献类型： 外文期刊

第一作者： Liu, Junyang

作者： Liu, Junyang;Mu, Qing;Gong, Wendian;Chahaer, Tergel;Song, Yukun;Hai, Erhan;Wang, Haoyuan;Zhang, Yanjun;Zhao, Yanhong;Mu, Qing;Chahaer, Tergel;Song, Yukun;Hai, Erhan;Wang, Haoyuan;Zhang, Yanjun;Zhao, Yanhong;Liu, Junyang;Liu, Bin;Liu, Jiasen;Li, Yunhua

作者机构：

关键词： Melatonin; miRNA; Dermal papilla cells; Chi-let-7d-5p; WNT2

期刊名称：GENOMICS （ 影响因子：3.0； 五年影响因子：3.3 ）

ISSN： 0888-7543

年卷期： 2024 年 116 卷 6 期

页码：

收录情况： SCI

摘要： Exogenous melatonin promotes the differentiation of secondary hair follicles in Cashmere goats, thereby improving cashmere production. MicroRNAs (miRNAs) play a crucial role in regulating post-transcriptional gene expression and influence hair follicle growth. However, the mechanism through which melatonin regulates hair follicle development via miRNA mediation remains unclear. In this study, we used RNA-seq to identify differentially expressed (DE) miRNAs during melatonin-induced growth of secondary hair follicles in inner Mongolian Cashmere goats. In total, 170 DE miRNAs were identified. Enrichment analysis revealed that the target genes of these DE miRNAs were related to biological processes such as protein modification; cytoskeletal components; and the Notch, Wnt, and MAPK signaling pathways. The miRNA-mRNA regulatory network suggested that the DE miRNA chi-let-7d-5p negatively regulates WNT2 expression. Mechanistic studies revealed that melatonin promotes the proliferation of DP cells in Cashmere goats via the chi-let-7d-5p/WNT2 axis.

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