Analysis of Copy Number Variation in the Whole Genome of Normal-Haired and Long-Haired Tianzhu White Yaks

文献类型： 外文期刊

第一作者： Meng, Guangyao

作者： Meng, Guangyao;Bao, Qi;Ma, Xiaoming;Chu, Min;Huang, Chun;Guo, Xian;Yan, Ping;Meng, Guangyao;Bao, Qi;Ma, Xiaoming;Chu, Min;Huang, Chun;Guo, Xian;Liang, Chunnian

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关键词： Tianzhu white yaks; copy number variation; long-haired trait; resequencing

期刊名称：GENES （ 影响因子：4.141； 五年影响因子：4.474 ）

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年卷期： 2022 年 13 卷 12 期

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收录情况： SCI

摘要： Long-haired individuals in the Tianzhu white yak population are a unique genetic resource, and have important landscape value. Copy number variation (CNV) is an important source of phenotypic variation in mammals. In this study, we used resequencing technology to detect the whole genome of 10 long-haired Tianzhu white yaks (LTWY) and 10 normal-haired Tianzhu white yaks (NTWY), and analyzed the differences of CNV in the genome of LTWYs and NTWYs. A total of 110268 CNVs were identified, 2006 CNVRs were defined, and the distribution map of these CNVRs on chromosomes was constructed. The comparison of LTWYs and NTWYs identified 80 differential CNVR-harbored genes, which were enriched in lipid metabolism, cell migration and other functions. Notably, some differential genes were identified as associated with hair growth and hair-follicle development (e.g., ASTN2, ATM, COL22A1, GK5, SLIT3, PM20D1, and SGCZ). In general, we present the first genome-wide analysis of CNV in LTWYs and NTWYs. Our results can provide new insights into the phenotypic variation of different hair lengths in Tianzhu white yaks.

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