Antioxidant Effects and Potential Mechanisms of Citrus reticulata 'Chachi' Components: An Integrated Approach of Network Pharmacology and Metabolomics

文献类型： 外文期刊

第一作者： Xiao, Jiahao

作者： Xiao, Jiahao;Shan, Yang;Li, Tao;Pan, Zhaoping;Li, Qili;Fu, Fuhua;Sun, Tian;Jiang, Shengyu;Xiao, Zhiqiang;Shan, Yang;Fu, Fuhua

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关键词： Citrus reticulata 'Chachi'; metabolomics; flavonoids; network pharmacology; antioxidant activity

期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）

ISSN：

年卷期： 2024 年 13 卷 24 期

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收录情况： SCI

摘要： Citrus reticulata 'Chachi' (CRC), recognized for its considerable edible and medicinal significance, is a valuable source of metabolites beneficial to human health. This research investigates the metabolic distinctions and antioxidant properties across four different parts of CRC, using multivariate statistical analysis to interpret metabolomic data and network pharmacology to identify potential antioxidant targets and relevant signaling pathways. The results indicate considerable metabolic differences in different parts of the sample, with 1622 metabolites showing differential expression, including 816 secondary metabolites, primarily consisting of terpenoids (31.02%) and flavonoids (25.22%). The dried mature citrus peel (CP) section demonstrates the highest level of total phenolics (6.8 mg/g), followed by the pulp without seed (PU) (4.52 mg/g), pulp with seed (PWS) (4.26 mg/g), and the seed (SE) (2.16 mg/g). Interestingly, targeted high-performance liquid chromatography of flavonoids reveals the highest level of nobiletin and tangeretin in CP, whereas PU has the highest level of hesperidin, narirutin, and didymin. Furthermore, all four sections of CRC exhibit robust antioxidant properties in in vitro assessments (CP > PU > PWS > SE). Lastly, the network pharmacology uncovered potential antioxidant mechanisms in CRC. This research offers deeper insights into the development and utilization of byproducts in the CRC processing industry.

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