A novel calcium-binding peptide from bovine bone collagen hydrolysate and chelation mechanism and calcium absorption activity of peptide-calcium chelate

文献类型： 外文期刊

第一作者： Qi, Liwei

作者： Qi, Liwei;Zhang, Hongru;Guo, Yujie;Zhang, Chunhui;Zhang, Hongru;Xu, Yang

作者机构：

关键词： Calcium-binding peptide; Calcium-sensing receptor; Chelation mechanism; Caco-2 cells

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2023 年 410 卷

页码：

收录情况： SCI

摘要： A novel calcium-binding peptide from bovine bone collagen hydrolysate was screened based on a new tar-get-the calcium-sensing receptor (CaSR), and its chelation mechanism and calcium absorption activity were investigated. Glu-Tyr-Gly exhibited superior binding affinities to CaSR because of its interaction with the active sites of the CaSR Venus Flytrap (VFT) domain. Glu-Tyr-Gly-Ca may exist in five potential chelation modes and its potential chelation mechanism was that calcium ions were located in the center and surrounded by ionic bonds (carboxyl group) and coordination bonds (carbonyl, amino, and carboxyl group). Glu-Tyr-Gly-Ca was slightly damaged in the intestinal fluid and at different temperatures, whereas it was severely damaged in the gastric fluid and acidic conditions. The results of the calcium dialysis percentage and Caco-2 cells experiments showed that Glu-Tyr-Gly-Ca possessed good calcium transport activity and bioavailability. The findings provided theo-retical basis for Glu-Tyr-Gly-Ca as potential calcium supplement to improve intestinal calcium absorption.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序