Butyrate limits the replication of porcine epidemic diarrhea virus in intestine epithelial cells by enhancing GPR43-mediated IFN-III production

文献类型： 外文期刊

第一作者： He, Haiyan

作者： He, Haiyan;Liu, Zhicheng;Zhang, Bin;Wuri, Nile;Geri, Letu;He, Haiyan;Fan, Xuelei;Shen, Haiyan;Gou, Hongchao;Zhang, Chunhong;Liu, Zhicheng;Zhang, Bin;Wuri, Nile;Zhang, Jianfeng;Liao, Ming;Fan, Xuelei;Shen, Haiyan;Gou, Hongchao;Zhang, Chunhong;Liu, Zhicheng;Zhang, Jianfeng;Liao, Ming;Shen, Haiyan;Gou, Hongchao;Zhang, Chunhong;Liu, Zhicheng;Zhang, Jianfeng;Liao, Ming

作者机构：

关键词： porcine epidemic diarrhea virus; butyrate; GPR43; intestinal epithelial cells; IFN-III

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.2； 五年影响因子：6.2 ）

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年卷期： 2023 年 14 卷

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收录情况： SCI

摘要： Porcine epidemic diarrhea virus (PEDV) is a threat to the health of newborn piglets and has a significant impact on the swine industry. Short-chain fatty acids (SCFAs) are gut microbial metabolites that regulate intestinal function through different mechanisms to enhance the intestinal barrier and immune function. In this study, we aimed to determine whether butyrate displayed a better effect than other SCFAs on limiting PEDV replication in porcine intestinal epithelial cells. Mechanistically, butyrate treatment activated the interferon (IFN) response and interferon-stimulated gene (ISG) expression. Further experiments showed that inhibition of GPR43 (free fatty acid receptor 2) in intestinal epithelial cells increased virus infection and reduced antiviral effects through IFN lambda response. Our findings revealed that butyrate exerts its antiviral effects by inducing GPR43-mediated IFN production in intestinal epithelial cells.

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