Nucleic Acid Nanotechnology: Trends, Opportunities and Challenges

文献类型： 外文期刊

第一作者： Singh, Raghvendra Pratap

作者： Singh, Raghvendra Pratap;Dubey, R. C.;Singh, Raghvendra Pratap;Dubey, R. C.;Singh, Raghvendra Pratap;Srivastava, Atul K.;Yang, Ying-Jie;Manchanda, Geetanjali;Kumar, Ajay;Yerpude, Sachin T.;Rai, Alok R.

作者机构：

关键词： DNA; RNA; nanostructure; DNA origami; SELEX; therapeutics; nucleic acid; nanotechnology

期刊名称：CURRENT PHARMACEUTICAL BIOTECHNOLOGY （ 影响因子：2.2； 五年影响因子：2.4 ）

ISSN： 1389-2010

年卷期： 2023 年 24 卷 1 期

页码：

收录情况： SCI

摘要： Nucleic acids (DNA and RNA) hold great potential for the advancement of future medicine but suffer from unsatisfactory clinical success due to the challenges accompanied with their delivery. Nucleic acid-mediated nanomaterials have riveted the researchers from the past two decades and exhilarating tasks have prevailed. Nucleic acid nanotechnology offers unique control over the shape, size, time, mechanics and anisotropy. It can transfect numerous types of tissues and cells without any toxic effect, minimize the induced immune response, and penetrate most of the biological barriers and hence it reveals itself as a versatile tool for multidisciplinary research field and for various therapeutic purposes. Nucleic acid combines with other nanoscale objects also by altering the chemical functional groups and reproducing the varied array of nanomaterials. Interestingly, nucleic acid-derived nanomaterials are characterized easily at atomic level accuracy. However, this advent of nanoscience has vital issues which must be addressed, such as the high cost of nucleic acids, their self-assembly nature, etc. Hence, the aim of this review is to highlight the systematic advances and methodology of nucleic acid-mediated synthesis of nanomaterials and their therapeutic applications.

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