Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness

文献类型： 外文期刊

第一作者： Luo, Ling-Yun

作者： Luo, Ling-Yun;Wu, Hui;Zhang, Ya-Hui;Huang, Jia-Hui;Mo, Dong-Xin;Li, Meng-Hua;Luo, Ling-Yun;Wu, Hui;Zhang, Ya-Hui;Huang, Jia-Hui;Mo, Dong-Xin;Li, Meng-Hua;Luo, Ling-Yun;Wu, Hui;Zhang, Ya-Hui;Huang, Jia-Hui;Mo, Dong-Xin;Li, Meng-Hua;Zhao, Li-Ming;Wang, Wei-Min;Zhao, Li-Ming;Wang, Wei-Min;Zhao, Li-Ming;Wang, Wei-Min;Zhao, Li-Ming;Wang, Wei-Min;Liu, Qiu-Yue;Wang, Hai-Tao;Eer, He-Hua;Zhang, Lian-Quan;Chen, Hai-Liang;Jia, Shan-Gang

作者机构：

期刊名称：NATURE GENETICS （ 影响因子：29.0； 五年影响因子：37.4 ）

ISSN： 1061-4036

年卷期： 2025 年 57 卷 1 期

页码：

收录情况： SCI

摘要： Ongoing efforts to improve sheep reference genome assemblies still leave many gaps and incomplete regions, resulting in a few common failures and errors in genomic studies. Here, we report a 2.85-Gb gap-free telomere-to-telomere genome of a ram (T2T-sheep1.0), including all autosomes and the X and Y chromosomes. This genome adds 220.05 Mb of previously unresolved regions and 754 new genes to the most updated reference assembly ARS-UI_Ramb_v3.0; it contains four types of repeat units (SatI, SatII, SatIII and CenY) in centromeric regions. T2T-sheep1.0 has a base accuracy of more than 99.999%, corrects several structural errors in previous reference assemblies and improves structural variant detection in repetitive sequences. Alignment of whole-genome short-read sequences of global domestic and wild sheep against T2T-sheep1.0 identifies 2,664,979 new single-nucleotide polymorphisms in previously unresolved regions, which improves the population genetic analyses and detection of selective signals for domestication (for example, ABCC4) and wool fineness (for example, FOXQ1).

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