Mobilome-driven partitions of the resistome in Salmonella

文献类型： 外文期刊

第一作者： Jia, Chenghao

作者： Jia, Chenghao;Wang, Zining;Huang, Chenghu;Teng, Lin;Zhou, Haiyang;An, Hongli;Liao, Sihao;Liu, Yuhao;Huang, Linlin;Yue, Min;Jia, Chenghao;Wang, Zining;Huang, Chenghu;Teng, Lin;Zhou, Haiyang;An, Hongli;Liao, Sihao;Liu, Yuhao;Huang, Linlin;Yue, Min;Wang, Zining;Huang, Chenghu;Zhou, Haiyang;An, Hongli;Liu, Yuhao;Yue, Min;Tang, Biao;Yue, Min

作者机构：

关键词： mobile genetic elements; resistome; complete genome sequence; Salmonella; horizontal gene transfer

期刊名称：MSYSTEMS （ 影响因子：6.4； 五年影响因子：7.3 ）

ISSN： 2379-5077

年卷期： 2023 年 8 卷 6 期

页码：

收录情况： SCI

摘要： Mobile genetic elements (MGEs) or mobilomes promote the mobilization and dissemination of antimicrobial resistance genes (ARGs), serving as critical drivers for antimicrobial resistance (AMR) accumulation, interaction, and persistence. However, systematic and quantitative evaluations of the role of mobilome in spreading resistome in a bacterial pathogen remain unaddressed, partially due to the lack of closed genomes. Here, we examined MGEs across 1,817 Salmonella isolates with complete genomic sequences from 58 countries between 1911 and 2022. We found the plasmid harboring 69.8% ARGs to be the largest ARG reservoir, correlated with serovar-based evolution in most Salmonella lineages. Prophages, specifically RCS47 and SJ46, play a crucial role in the plasmids' plasticity and the acquisition of ARGs. Furthermore, distinct ARG accumulation, including resistance toward last-resort antibiotics, exhibited an MGE-favored manner. Certain socioeconomic and ecological factors, as additional layers of mediators, are associated with the preferential distribution of MGE-mediated ARGs in Salmonella. Collectively, this study demonstrated an uncharted knowledge of the segmentation of Salmonella resistome driven by mobilome, elucidating dynamic drivers and distinct mediators for resistome development that are of immediate relevance for targeted interventions.

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[1]Mobilome-driven partitions of the resistome in Salmonella. Jia, Chenghao,Wang, Zining,Huang, Chenghu,Teng, Lin,Zhou, Haiyang,An, Hongli,Liao, Sihao,Liu, Yuhao,Huang, Linlin,Yue, Min,Jia, Chenghao,Wang, Zining,Huang, Chenghu,Teng, Lin,Zhou, Haiyang,An, Hongli,Liao, Sihao,Liu, Yuhao,Huang, Linlin,Yue, Min,Wang, Zining,Huang, Chenghu,Zhou, Haiyang,An, Hongli,Liu, Yuhao,Yue, Min,Tang, Biao,Yue, Min. 2023

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