Ssc-miR-7139-3p suppresses foot-and-mouth disease virus replication by promoting degradation of 3Cpro through targeting apoptosis-negative regulatory gene Bcl-2

文献类型： 外文期刊

第一作者： Wang, Kailing

作者： Wang, Kailing;Wang, Xiangwei;Wang, Guangxiang;Afera, Tadele Berihun;Hou, Shitong;Yao, Kaishen;Wang, Shasha;Sun, Yuefeng;Zhang, Jie;Afera, Tadele Berihun

作者机构：

关键词： miR-7139-3p; FMDV; Apoptosis; 3C; Bcl-2

期刊名称：VIROLOGY （ 影响因子：3.7； 五年影响因子：3.2 ）

ISSN： 0042-6822

年卷期： 2024 年 595 卷

页码：

收录情况： SCI

摘要： Foot-and-mouth disease is a highly contagious and infectious disease affecting cloven-hoofed animals. Disease control is complicated by its highly contagious nature and antigenic diversity. Host microRNAs (miRNAs) are post-transcriptional regulators that either promote or repress viral replications in virus infection. In the present study, we found that ssc-miR-7139-3p (Sus scrofa miR-7139-3p) was significantly up-regulated in host cells during foot-and-mouth disease virus (FMDV) infection. Overexpression of miR-7139-3p attenuated FMDV replication, whereas inhibition promoted FMDV replication. In addition, the survival rate of FMDV infected suckling mice was increased through injection of miR-7139-3p agomiR. Further studies revealed that miR-7139-3p targets Bcl-2 to initiate the apoptotic pathway and caspase-3 cleaved 3C(pro) behind the 174th aspartic acid (D174), which eventually promotes the degradation of 3C(pro). Overall, our findings demonstrate that miR-7139-3p suppresses FMDV replication by promoting degradation of 3C(pro) through targeting the apoptosis-negative regulatory gene Bcl-2.

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