An epigenetic basis of inbreeding depression in maize

文献类型： 外文期刊

第一作者： Han, Tongwen

作者： Han, Tongwen;Wang, Fang;Song, Qingxin;Ye, Wenxue;Liu, Tieshan;Wang, Liming;Chen, Z. Jeffrey;Chen, Z. Jeffrey

作者机构：

期刊名称：SCIENCE ADVANCES （ 影响因子：14.143； 五年影响因子：16.45 ）

ISSN： 2375-2548

年卷期： 2021 年 7 卷 35 期

页码：

收录情况： SCI

摘要： Inbreeding depression is widespread across plant and animal kingdoms and may arise from the exposure of deleterious alleles and/or loss of overdominant alleles resulting from increased homozygosity, but these genetic models cannot fully explain the phenomenon. Here, we report epigenetic links to inbreeding depression in maize. Teosinte branched1/cycloidea/proliferating cell factor (TCP) transcription factors control plant development. During successive inbreeding among inbred lines, thousands of genomic regions across TCP-binding sites (TBS) are hypermethylated through the H3K9me2-mediated pathway. These hypermethylated regions are accompanied by decreased chromatin accessibility, increased levels of the repressive histone marks H3K27me2 and H3K27me3, and reduced binding affinity of maize TCP-proteins to TBS. Consequently, hundreds of TCP-target genes involved in mitochondrion, chloroplast, and ribosome functions are down-regulated, leading to reduced growth vigor. Conversely, random mating can reverse corresponding hypermethylation sites and TCP-target gene expression, restoring growth vigor. These results support a unique role of reversible epigenetic modifications in inbreeding depression.

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