Genomic insights into a clinical Salmonella Typhimurium isolate carrying plasmid-me diate d blaNDM-5

文献类型： 外文期刊

第一作者： Huang, Fan

作者： Huang, Fan;Huang, Xu;Guo, Genglin;Feng, Lu;Cai, Tongbo

作者机构：

关键词： Salmonella Typhimurium; Whole-genome sequencing; Bla NDM-5

期刊名称：JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE （ 影响因子：3.2； 五年影响因子：3.8 ）

ISSN： 2213-7165

年卷期： 2025 年 40 卷

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收录情况： SCI

摘要： Objective: Highly carbapenem-resistant Salmonella has emerged worldwide in recent years and is largely associated with the multiform transmission of resistance genes, which poses a huge challenge in clinical practice. Our study delves into the resistance mechanisms and epidemiology of bla NDM-carrying plasmids. Methods: Whole-genome sequencing was utilised to analyse the molecular characteristics and antimicrobial resistance mechanisms of Salmonella isolates recovered from the faeces of a paediatric patient at the Children's Hospital of Nanjing Medical University. Moreover, we conducted an epidemiologic analysis and focused on studying the mechanisms of plasmid-mediated bla NDM transmission, incorporating genomes deposited in the NCBI Pathogen Detection database. Results: The clinical isolate 23S9 belonged to serovar Typhimurium, antigenic profile 4:i:-, ST34, and carried pNDM_23S9 harbouring several antimicrobial resistance genes, including aac(6')-Ib-cr6, OXA-1, catB3, arr-3, qacEdeltal and bla NDM . Comparative analysis revealed that bla NDM-5 can exist in different plasmids of different isolates, proving its transmission through plasmids. Furthermore, bla NDM-carrying isolates are mostly resistant to beta-lactams, aminoglycosides, sulphonamide, macrolides, and trimethoprim. Conclusions: These findings provided thorough and intuitive insights into the intercontinental spread of bla NDM-carrying Salmonella . Ongoing surveillance is essential for effectively monitoring the worldwide dissemination of this high-risk carbapenem-resistant Salmonella . (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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