Cellular differentiation into hyphae and spores in halophilic archaea

文献类型： 外文期刊

第一作者： Tang, Shu-Kun

作者： Tang, Shu-Kun;Zhi, Xiao-Yang;Liu, Bing-Bing;Zhao, Yu-Rong;Li, En-Yuan;Feng, Yu-Zhou;Xiang, Ming-Xian;Lin, Zhi-Qian;Li, Rui;Yin, Min;Yang, Ling-Ling;Zhang, Yao;Zhang, Zhen-Peng;Jiang, Song-Hao;Zhang, Tao;Chen, Pei-Ru;Shi, Jia-Hui;Chang, Cheng;Chang, Lei;Gao, Hui-Ying;He, Fu-Chu;Xu, Ping;Makarova, Kira S.;Wolf, Yuri I.;Koonin, Eugene V.;Liu, Bing-Bing;Zhang, Xue;Zheng, Guo-Song;Lu, Yin-Hua;Zheng, Hua-Jun;Zheng, Hua-Jun;Jiang, Song-Hao;Chen, Pei-Ru;Shi, Jia-Hui;Xu, Ping;Chen, Xi-Ming;Lou, Kai;Wang, Yun;Zhang, Zhong-Kai;Tao, Tian-Shen;Xu, Ping;Guan, Tong-Wei;Cui, Heng-Lin;Zhao, Guo-Ping;Zhao, Guo-Ping;Xu, Ping;Xu, Ping

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：16.6； 五年影响因子：17.0 ）

ISSN：

年卷期： 2023 年 14 卷 1 期

页码：

收录情况： SCI

摘要： Several groups of bacteria have complex life cycles involving cellular differentiation and multicellular structures. For example, actinobacteria of the genus Streptomyces form multicellular vegetative hyphae, aerial hyphae, and spores. However, similar life cycles have not yet been described for archaea. Here, we show that several haloarchaea of the family Halobacteriaceae display a life cycle resembling that of Streptomyces bacteria. Strain YIM 93972 (isolated from a salt marsh) undergoes cellular differentiation into mycelia and spores. Other closely related strains are also able to form mycelia, and comparative genomic analyses point to gene signatures (apparent gain or loss of certain genes) that are shared by members of this clade within the Halobacteriaceae. Genomic, transcriptomic and proteomic analyses of non-differentiating mutants suggest that a Cdc48-family ATPase might be involved in cellular differentiation in strain YIM 93972. Additionally, a gene encoding a putative oligopeptide transporter from YIM 93972 can restore the ability to form hyphae in a Streptomyces coelicolor mutant that carries a deletion in a homologous gene cluster (bldKA-bldKE), suggesting functional equivalence. We propose strain YIM 93972 as representative of a new species in a new genus within the family Halobacteriaceae, for which the name Actinoarchaeum halophilum gen. nov., sp. nov. is herewith proposed. Our demonstration of a complex life cycle in a group of haloarchaea adds a new dimension to our understanding of the biological diversity and environmental adaptation of archaea. Bacteria of the genus Streptomyces have complex life cycles involving cellular differentiation and multicellular structures that have never been observed in archaea. Here, the authors show that several halophilic archaea display a life cycle resembling that of Streptomyces bacteria, undergoing cellular differentiation into mycelia and spores.

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