Three chromosome-level duck genome assemblies provide insights into genomic variation during domestication

文献类型： 外文期刊

第一作者： Zhu, Feng

作者： Zhu, Feng;Yin, Zhong-Tao;Wang, Zheng;Zhang, Fan;Lin, Fang-Bing;Zhao, Qiang-Sen;Li, Xiao-Qin;Ding, Si-Ran;Li, Guan-Sheng;Yang, Ning;Hou, Zhuo-Cheng;Zhu, Feng;Yin, Zhong-Tao;Wang, Zheng;Zhang, Fan;Lin, Fang-Bing;Zhao, Qiang-Sen;Li, Xiao-Qin;Ding, Si-Ran;Li, Guan-Sheng;Yang, Ning;Hou, Zhuo-Cheng;Zhu, Feng;Yin, Zhong-Tao;Wang, Zheng;Zhang, Fan;Lin, Fang-Bing;Zhao, Qiang-Sen;Li, Xiao-Qin;Ding, Si-Ran;Li, Guan-Sheng;Yang, Ning;Hou, Zhuo-Cheng;Smith, Jacqueline;Burt, David W.;Smith, Jacqueline;Burt, David W.;Martin, Fergal;Ogeh, Denye;Hincke, Maxwell;Burt, David W.;Zhou, Zheng-Kui;Hou, Shui-Sheng;Zhou, Zheng-Kui;Hou, Shui-Sheng;Yang, Fang-Xi;Hao, Jing-Pin;Zhang, Ziding;Lu, Li-Zhi

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN：

年卷期： 2021 年 12 卷 1 期

页码：

收录情况： SCI

摘要： Domestic ducks are raised for meat, eggs and feather down, and almost all varieties are descended from the Mallard (Anas platyrhynchos). Here, we report chromosome-level high-quality genome assemblies for meat and laying duck breeds, and the Mallard. Our new genomic databases contain annotations for thousands of new protein-coding genes and recover a major percentage of the presumed "missing genes" in birds. We obtain the entire genomic sequences for the C-type lectin (CTL) family members that regulate eggshell biomineralization. Our population and comparative genomics analyses provide more than 36 million sequence variants between duck populations. Furthermore, a mutant cell line allows confirmation of the predicted anti-adipogenic function of NR2F2 in the duck, and uncovered mutations specific to Pekin duck that potentially affect adipose deposition. Our study provides insights into avian evolution and the genetics of oviparity, and will be a rich resource for the future genetic improvement of commercial traits in the duck. Domestic ducks are descended from the Mallard and have been bred for several purposes. Here the authors present three high-quality duck genome assemblies which recover previously missing genes and provide a rich resource of variants potentially related to domestication.

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