Live Attenuated aTJ Vaccine Effectively Protects Pigeons Against Homologous PPMV-1 Challenge

文献类型： 外文期刊

第一作者： Zhang, Shan

作者： Zhang, Shan;Liu, Dahu;Liang, Ruinying;Liang, Lin;Tang, Xinming;Hou, Shaohua;Ding, Jiabo;Liu, Baojing;Ding, Chan;Qiu, Xusheng

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关键词： PPMV-1; reverse genetics; aTJ strain; booster immunization; vaccine efficacy

期刊名称：VACCINES （ 影响因子：3.4； 五年影响因子：3.7 ）

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年卷期： 2024 年 12 卷 12 期

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收录情况： SCI

摘要： Background: Pigeon paramyxovirus type 1 (PPMV-1) is a significant pathogen affecting pigeon populations globally. The commonly used La Sota vaccine provides limited protection due to antigenic divergence from circulating PPMV-1 strains. An antigenically matched vaccine is needed to address this challenge. Methods: An attenuated aTJ strain was developed through reverse genetics by modifying the F protein cleavage site of the virulent TJ-WT strain. Pigeons were immunized twice with the aTJ strain via eyedrop and intranasal routes, followed by a challenge with a virulent PPMV-1 strain ten days after the booster immunization. Results: The attenuated aTJ strain induced robust serum antibody titers post-booster immunization, and vaccinated pigeons showed strong protection upon challenge, with significantly reduced morbidity, mortality, and viral shedding compared to controls. Conclusions: These findings suggest that the aTJ strain is a promising candidate for the promotion of PPMV-1 prevention and control, emphasizing the importance of antigenic matching in optimizing vaccine efficacy.

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