Key Regulators of Autophagosome Closure

文献类型： 外文期刊

第一作者： Jiang, Wenyan

作者： Jiang, Wenyan;Chen, Xuechai;Ji, Cuicui;Zhang, Wenting;Song, Jianing;Wang, Juan;Li, Jie

作者机构：

关键词： autophagy; autophagosome; closure; isolation membrane

期刊名称：CELLS （ 影响因子：6.6； 五年影响因子：6.663 ）

ISSN：

年卷期： 2021 年 10 卷 11 期

页码：

收录情况： SCI

摘要： Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are sequestered within double-membrane vesicles called autophagosomes and then transported into lysosomes or vacuoles for degradation. Over 40 conserved autophagy-related (ATG) genes define the core machinery for the five processes of autophagy: initiation, nucleation, elongation, closure, and fusion. In this review, we focus on one of the least well-characterized events in autophagy, namely the closure of the isolation membrane/phagophore to form the sealed autophagosome. This process is tightly regulated by ESCRT machinery, ATG proteins, Rab GTPase and Rab-related proteins, SNAREs, sphingomyelin, and calcium. We summarize recent progress in the regulation of autophagosome closure and discuss the key questions remaining to be addressed.

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