The N6-methyladenosine binding proteins YTH03/05/10 coordinately regulate rice plant height

文献类型： 外文期刊

第一作者： Cai, Long

作者： Cai, Long;Cui, Song;Jin, Tao;Huang, Xiaolong;Hou, Haigang;Hao, Benyuan;Xu, Zhuang;Cai, Liang;Hu, Yuan;Yang, Xue;Zhou, Lei;Yu, Ting;Tian, Yunlu;Liu, Xi;Chen, Liangming;Liu, Shijia;Jiang, Ling;Zhou, Shirong;Wan, Jianmin;Wan, Jianmin

作者机构：

关键词： Oryza sativa L; YTH family protein; M6A binding protein; Plant height

期刊名称：PLANT SCIENCE （ 影响因子：5.2； 五年影响因子：5.7 ）

ISSN： 0168-9452

年卷期： 2023 年 329 卷

页码：

收录情况： SCI

摘要： N6-methyladenosine (m6A) is the most widely distributed and most abundant type of mRNA modification in eukaryotic. It provides a posttranscriptional level regulation of gene expression by regulating pre-mRNA splicing, mRNA degradation, or mRNA translational efficiency etc. The function of m6A modification is decoded by binding proteins that can specially bind to m6A. YT521-B homology (YTH) family proteins are the most important m6A-binding proteins in mammals and Arabidopsis. However, their roles in growth and development remain unknown. Here, we demonstrated that the YTH family proteins YTH03, YTH05 and YTH10 specifically bind to m6A-containing RNAs. Knockout of YTH03, YTH05 or YTH10 causes reduced plant height. Further research showed that simultaneously knockout of YTH03, YTH05 and YTH10 shows severe dwarf phenotype, suggesting these three genes regulate rice plant height in a functionally redundant manner. Additional tran- scriptome study showed that the reduced plant height of the yth03/05/10 triple mutant may be due to the blocked of diterpenoid and brassinolide synthesis pathway. Overall, we demonstrate that YTH03, YTH05 and YTH10 are all the m6A readers in rice and redundantly regulate rice plant height through the hormonal related pathway.

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