Enantioselective Synthesis of Dispirooxindole Derivatives via Asymmetric Catalytic Cascade Reactions
文献类型： 外文期刊
第一作者： Ma, Rui
作者： Ma, Rui;Zhang, Jia-Lu;Hu, Xiu-Qin;Xu, Peng-Fei;Xu, Peng-Fei;Xu, Peng-Fei
作者机构：
关键词： organocatalysis; dispirooxindole; cascade reactions; four contiguous stereogenic centers; new substrates
期刊名称：SYNTHESIS-STUTTGART （ 影响因子：2.6； 五年影响因子：2.4 ）
ISSN： 0039-7881
年卷期： 2023 年 55 卷 12 期
页码：
收录情况： SCI
摘要： A series of optically active 3,3 '-pyrrolidinyl-dispirooxindole derivatives containing a CF3 moiety have been efficiently constructed through asymmetric catalytic cascade reactions catalyzed by cinchona derived bifunctional squaramide catalyst, bearing four contiguous stereogenic centers, two of which are vicinal spiro-stereocenters. Additionally, a wide range of substituted products were achieved with moderate to high yields (up to 99% yield) and excellent stereoselectivities (up to > 20:1 dr for all cases and up to 99% ee).
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