β-Glucan from Lyophyllum decastes regulates gut microbiota and plasma metabolites in high-fat diet-induced obese mice

文献类型： 外文期刊

第一作者： Sun, Bin

作者： Sun, Bin;Zhang, Fangfang;Pan, Liang;Yu, Ling;Ye, Lin;Huang, Zhenzhen;Xiao, Ying;Liu, Xiaodan;Sun, Bin;Liu, Yanfang;Xu, Qi;Liu, Jieying;Yan, Shiyue

作者机构：

关键词： Lyophyllum decastes beta-glucan; Gut microbiota; Plasma metabolomic; Dyslipidemia; Obesity

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）

ISSN： 1756-4646

年卷期： 2024 年 116 卷

页码：

收录情况： SCI

摘要： This study aimed to investigate the effects of Lyophyllum decastes beta- glucan (LDBG) in preventing high-fat diet (HFD)-induced obesity in male C57BL/6 mice, focusing on fecal gut microbiota (GM) and plasma metabolomics. LDBG treatment led to a reduction in body weight and an improvement in dyslipidemia in the HFD-fed mice. Additionally, LDBG decreased pro-inflammatory factors (TNF-alpha, IL-1 beta, and IL -6) in liver and abdominal adipose tissue and lowered lipopolysaccharide and leptin levels in plasma. LDBG also up-regulated mRNA levels of intestinal epithelial tight junction proteins, such as Occludin, Claudin-1, and zonula occludens-1 in colon tissue. Furthermore, 16S rRNA gene sequencing data suggested that LDBG reduced the relative abundance of Faecalibaculum and Ileibacterium while increasing that of Bifidobacterium and Oscillospiraceae . Untargeted metabolomics showed that LDBG significantly promoted Tryptophan metabolism, Glycerophospholipid metabolism, and the Citrate cycle, closely correlating with GM changes, particularly in Oscillospiraceae genera. This study demonstrates the potential of LDBG as a prebiotic in obesity prevention by regulating metabolite pathways.

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