Rabies virus-based oral and inactivated vaccines protect minks against SARS-CoV-2 infection and transmission

文献类型： 外文期刊

第一作者： Huo, Hong

作者： Huo, Hong;Xiao, Shuang;Wang, Jinming;Wang, Xijun;Ge, Jinying;Zhong, Gongxun;Wen, Zhiyuan;Wang, Chong;Wang, Jinliang;Wang, Han;Shuai, Lei;Bu, Zhigao;Huo, Hong;Zhong, Gongxun;Wen, Zhiyuan;Wang, Chong;Wang, Jinliang;He, Xijun;Shuai, Lei;Bu, Zhigao;Bu, Zhigao

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关键词： SARS-CoV-2; rabies virus; oral vaccine; inactivated vaccine; mink

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 影响因子：4.4； 五年影响因子：4.8 ）

ISSN： 2095-3119

年卷期： 2025 年 24 卷 3 期

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收录情况： SCI

摘要： Minks are highly susceptible to SARS-CoV-2, and have transmitted SARS-CoV-2 to humans. Oral immunization is one of the most promising strategies to prevent SARS-CoV-2 infection and transmission in minks. Here, we generated 3 recombinant rabies viruses (RABV), rERAG333E/S6P, rERAG333E/DS6P and rERAG333E/BA2S6P, expressing the prefusion-stabilized SARS-CoV-2 spike protein of wild-type (S6P), delta (DS6P) or BA.2 (BA2S6P) strain based on an oral rabies vaccine candidate (rERAG333E). Oral or inactivated immunization of the 3 RABVs monovalent or trivalent were safe, and induced robust RABV neutralizing antibody and cross-antibody responses against the three SARS-CoV-2 in mice and minks. The challenge tests showed that 2 doses of rERAG333E-S6P as an oral or inactivated vaccine completely protected mice against mouse-adapted SARS-CoV-2 infection in the upper and lower respiratory tracts, and largely prevented viral replication and lung damage caused by wild-type SARS-CoV-2 infection in minks. Notably, we also confirmed that 2 doses of rERAG333E-S6P as an oral or inactivated vaccine can largely protect minks against wild-type SARS-CoV-2 transmission via respiratory droplets. Our findings suggest that rERAG333E-based COVID-19 vaccines appear to be suitable oral candidates to protect minks from SARS-CoV-2 infection and transmission, and may serve as inactivated vaccines for further investigation in humans.

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