Vincan- and eburnan-type alkaloids from Tabernaemontana bovina and their hypoglycemic activity

文献类型： 外文期刊

第一作者： Yu, Yang

作者： Yu, Yang;Bao, Mei-Fen;Wu, Jing;Cai, Xiang-Hai;Huang, Sheng-Zhuo

作者机构：

关键词： Tabernaemontana bovina; Apocynaceae; Vincan-type alkaloids; Eburnan-type alkaloids; Hypoglycemic activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）

ISSN： 0031-9422

年卷期： 2021 年 190 卷

页码：

收录情况： SCI

摘要： Thirty-one Vincan-and two Eburnan-type alkaloids were isolated from the aerial parts of Tabernaemontana bovina, whereas 20 of them are described the first time. Within the purified alkaloids, the firstly described taberbovcamine A features a 6/5/6/6/5 ring system. All the chemical structures were elucidated by employing extensive spectroscopic, computational electronic circular dichroism and X-ray diffraction methods. The two Eburnan-type alkaloids, 10,11-dimethoxy-16-O-methyllisoeburnamenine and 10,11-dimethoxy-isoeburnamenine were simultaneously identified by using the mentioned spectroscopic methods. Within the identified alkaloids, 10-hydroxy-14,15-didehydrovincanmine, 14,15-didehydrovincanmine, 14,15-didehydroapovincanmine, and criocerine increased the glucose consumption in a L6 myotube model.

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