Aggregation-induced electrochemiluminescence and molecularly imprinted polymer based sensor with Fe3O4@Pt nanoparticle amplification for ultrasensitive ciprofloxacin detection

文献类型： 外文期刊

第一作者： Li, Shuhuai

作者： Li, Shuhuai;Pang, Chaohai;Ma, Xionghui;Wu, Yuwei;Wang, Mingyue;Xu, Zhi;Luo, Jinhui

作者机构：

关键词： Aggregation-induced electrochemiluminescence; Molecularly imprinted polymer; Nanozyme; Ciprofloxacin; Sensor

期刊名称：MICROCHEMICAL JOURNAL （ 影响因子：5.304； 五年影响因子：4.723 ）

ISSN： 0026-265X

年卷期： 2022 年 178 卷

页码：

收录情况： SCI

摘要： To broaden the applicability of electrochemiluminescence (ECL) sensors toward the sensitive and selective detection of trace antibiotic residues, new ECL reagents are required. Herein, a novel molecularly imprinted sensor based on an aggregation-induced ECL reagent was fabricated for the sensitive detection of ciprofloxacin (CFX). A covalent organic framework with aggregation-induced ECL (COF-AIECL) was synthesised using a boric acid condensation dehydration reaction. Then, an electrode surface was modified with COF-AIECL as a signal element and nanozymatic ferriferrous oxide@platinum nanoparticles (Fe3O4@Pt NPs) as a signal amplification element. Subsequently, using CFX as a template molecule, a molecularly imprinted polymer (MIP) was fabricated on the modified electrode. The ECL signal of COF-AIECL was catalytically amplified by the Fe3O4@Pt NPs, whereas CFX effectively quenched this signal. Consequently, the ECL signal was controlled by CFX elution from and adsorption by the MIP, thus establishing a new method for CFX detection. The sensitivity of the sensor was greatly enhanced by the aggregation-induced luminescence effect and nanozyme amplification, whereas the MIP effectively improved the selectivity for CFX. Under optimal conditions, the electrochemical sensor exhibited a linear detection range of 2 x 10(-12) to 3 x 10(-9) mol L-1, with a detection limit of 5.98 x 10(-13) mol L-1. Furthermore, in untreated milk samples, CFX recoveries of 92.0%-111% were achieved. Thus, the developed sensor exhibited good reproducibility, stability, and selectivity for CFX detection.

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