文献类型： 外文期刊
第一作者： Wang, Qing
作者： Wang, Qing;Huang, Chen;Zhang, Meng-Qi;Guo, Xu;Liu, Chao;Sun, Jin-Yue;Rong, Yao;Smith, Mark A.
作者机构：
关键词： Polygala seed oil; Sn-2-acTAG; Hypolipidemic effect; Toxicity; Mechanism
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2023 年 111 卷
页码：
收录情况： SCI
摘要： A new class of 2-acetyl-1,3-diacyl-sn-glycerols (sn-2-acTAG) was found in the seed oil of Polygala previously. Its structure is very similar to sn-1,3-DAG, which has effect of preventing and treating hyperlipidemia and other diseases. In this study, sn-2-acTAG was enriched and confirmed, the safety and the hypolipidemic activity was assessed. In addition the mechanism of action was investigated. Our study indicated that a diet containing 20% sn-2-acTAG or lower was not toxic to SD rats. Compared to the soybean oil group, sn-2-acTAG could lower the total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels, as well as rise the level of high -density lipoprotein cholesterol. Sn-2-acTAG could regulate the expression of proinflammatory factors to ameliorate hyperlipidemia. In conclusion, sn-2-acTAG has for the first time been found to significantly ameliorate hyperlipidemia in the high-fat diet rat. This study will provide a strong theoretical support for the efficient development and application of Polygala seed oil.
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