A molecular link between autophagy and circadian rhythm in plants

文献类型： 外文期刊

第一作者： Chen, Weijun

作者： Chen, Weijun;Hu, Zhaotun;Zhu, Sirui;Song, Limei;Yu, Feng;Chen, Weijun;Hu, Zhaotun;Zhu, Sirui;Song, Limei;Yu, Feng;Hu, Zhaotun;Yu, MengTing;Xing, Junjie;Yu, Feng;Pu, Wenxuan

作者机构：

关键词： ATG8d; autophagy activities; circadian clock; nutritional stress; TOC1

期刊名称：JOURNAL OF INTEGRATIVE PLANT BIOLOGY （ 影响因子：9.106； 五年影响因子：8.241 ）

ISSN： 1672-9072

年卷期： 2022 年 64 卷 5 期

页码：

收录情况： SCI

摘要： Extremely high or low autophagy levels disrupt plant survival under nutrient starvation. Recently, autophagy has been reported to display rhythms in animals. However, the mechanism of circadian regulation of autophagy is still unclear. Here, we observed that autophagy has a robust rhythm and that various autophagy-related genes (ATGs) are rhythmically expressed in Arabidopsis. Chromatin immunoprecipitation (ChIP) and dual-luciferase (LUC) analyses showed that the core oscillator gene TIMING OF CAB EXPRESSION 1 (TOC1) directly binds to the promoters of ATG (ATG1a, ATG2, and ATG8d) and negatively regulates autophagy activities under nutritional stress. Furthermore, autophagy defects might affect endogenous rhythms by reducing the rhythm amplitude of TOC1 and shortening the rhythm period of CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1). Autophagy is essential for the circadian clock pattern in seedling development and plant sensitivity to nutritional deficiencies. Taken together, our studies reveal a plant strategy in which the TOC1-ATG axis involved in autophagy-rhythm crosstalk to fine-tune the intensity of autophagy.

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