Different Types of Vaccines against Pestiviral Infections: "Barriers" for "Pestis"

文献类型： 外文期刊

第一作者： Yuan, Mengqi

作者： Yuan, Mengqi;Yang, Xiaoke;Zhang, Xin;Zhao, Xiaotian;Qiu, Hua-Ji;Li, Yongfeng;Zhang, Xin;Zhao, Xiaotian;Qiu, Hua-Ji;Abid, Muhammad

作者机构：

关键词： pestiviruses; live attenuated vaccines; marker vaccines; multivalent vaccines

期刊名称：VIRUSES-BASEL （ 影响因子：4.7； 五年影响因子：4.8 ）

ISSN：

年卷期： 2023 年 15 卷 1 期

页码：

收录情况： SCI

摘要： The genus Pestivirus of the family Flaviviridae mainly comprises classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and multiple new pestivirus species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus. Pestiviruses cause infectious diseases, resulting in tremendous economic losses to animal husbandry. Different types of pestivirus vaccines have been developed to control and prevent these important animal diseases. In recent years, pestiviruses have shown great potential as viral vectors for developing multivalent vaccines. This review analyzes the advantages and disadvantages of various pestivirus vaccines, including live attenuated pestivirus strains, genetically engineered marker pestiviruses, and pestivirus-based multivalent vaccines. This review provides new insights into the development of novel vaccines against emerging pestiviruses, such as APPV and ovine pestivirus.

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