文献类型： 外文期刊
第一作者： Wang, Xiao
作者： Wang, Xiao;Liu, Tian-Xia;Zhang, Ying;Zhao, Jian-Guo;Liu, Tian-Xia;Zhao, Jian-Guo;Wang, Xiao;Zhang, Ying;Zhao, Jian-Guo;Wang, Xiao;Zhang, Ying;Zhao, Jian-Guo;Xu, Liang-Wei;Yuan, Shuo-Long;Guo, Wei -Wei;Yang, Shi-Ming;Cui, A. -Long;Wang, Xiao;Wang, Yan-Fang
作者机构：
关键词： Pigs; Animal models; Hereditary hearing loss; Genetic modification; Inner ear
期刊名称：ZOOLOGICAL RESEARCH （ 影响因子：4.9； 五年影响因子：4.6 ）
ISSN： 2095-8137
年卷期： 2024 年 45 卷 2 期
页码：
收录情况： SCI
摘要： Hereditary hearing loss (HHL), a genetic disorder that impairs auditory function, significantly affects quality of life and incurs substantial economic losses for society. To investigate the underlying causes of HHL and evaluate therapeutic outcomes, appropriate animal models are necessary. Pigs have been extensively used as valuable large animal models in biomedical research. In this review, we highlight the advantages of pig models in terms of ear anatomy, inner ear morphology, and electrophysiological characteristics, as well as recent advancements in the development of distinct genetically modified porcine models of hearing loss. Additionally, we discuss the prospects, challenges, and recommendations regarding the use pig models in HHL research. Overall, this review provides insights and perspectives for future studies on HHL using porcine models.
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