Effect of SNPs on Litter Size in Swine

文献类型： 外文期刊

第一作者： Guo, Zhenhua

作者： Guo, Zhenhua;Liu, Di;Ma, Hong;Lv, Lei;Radovic, Cedomir

作者机构：

关键词： gene set enrichment analysis; litter size; network meta-analysis; single-nucleotide polymorphism; PCR-RFLP/SSCP

期刊名称：CURRENT ISSUES IN MOLECULAR BIOLOGY （ 影响因子：2.8； 五年影响因子：2.9 ）

ISSN： 1467-3037

年卷期： 2024 年 46 卷 7 期

页码：

收录情况： SCI

摘要： Although sows do not directly enter the market, they play an important role in piglet breeding on farms. They consume large amounts of feed, resulting in a significant environmental burden. Pig farms can increase their income and reduce environmental pollution by increasing the litter size (LS) of swine. PCR-RFLP/SSCP and GWAS are common methods to evaluate single-nucleotide polymorphisms (SNPs) in candidate genes. We conducted a systematic meta-analysis of the effect of SNPs on pig LS. We collected and analysed data published over the past 30 years using traditional and network meta-analyses. Trial sequential analysis (TSA) was used to analyse population data. Gene set enrichment analysis and protein-protein interaction network analysis were used to analyse the GWAS dataset. The results showed that the candidate genes were positively correlated with LS, and defects in PCR-RFLP/SSCP affected the reliability of candidate gene results. However, the genotypes with high and low LSs did not have a significant advantage. Current breeding and management practices for sows should consider increasing the LS while reducing lactation length and minimizing the sows' non-pregnancy period as much as possible.

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