High-fiber diet ameliorates gut microbiota, serum metabolism and emotional mood in type 2 diabetes patients

文献类型： 外文期刊

第一作者： Chen, Lihua

作者： Chen, Lihua;Liu, Bo;Ren, Lixia;Li, Zongjie;Du, Hao;Fei, Chunhua;Qian, Chang;Li, Bin;Zhang, Ruixia;Liu, Haixia;Li, Zongjie;Ma, Zhiyong

作者机构： Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai, Peoples R China;Mental Hlth Ctr Fengxian Dist, Dept Gastroenterol, Shanghai, Peoples R China;Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Shanghai, Peoples R China;Sinosci Yikang Beijing Biotech Co Ltd, Safety & Qual Management Dept, Beijing, Peoples R China;Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai, Peoples R China

关键词： dietary fiber; gut microbiota; serum metabolome; depression; anxiety; type 2 diabetes mellitus

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 2022影响因子：5.7； 五年影响因子：5.9 ）

ISSN： 2235-2988

年卷期： 2023 年 13 卷

页码：

收录情况： SCI

摘要： Previous studies have demonstrated that patients with type 2 diabetes mellitus (T2DM) often had the problems of fecal microbiota dysbiosis, and were usually accompanied with psychiatric comorbidities (such as depression and anxiety). Here, we conducted a randomized clinical study to analyze the changes in gut microbiota, serum metabolism and emotional mood of patients with T2DM after consumption of a high-fiber diet. The glucose homeostasis of participants with T2DM was improved by the high-fiber diet, and the serum metabolome, systemic inflammation and psychiatric comorbidities were also altered. The increased abundances of Lactobacillus, Bifidobacterium and Akkermansias revealed that the proportions of beneficial gut microbes were enriched by the high-fiber diet, while the abundances of Desulfovibrio, Klebsiella and other opportunistic pathogens were decreased. Therefore, the current study demonstrated that the intestinal microbiota alterations which were influenced by the high-fiber diet could improve the serum metabolism and emotional mood of patients with T2DM.

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