A chromosome-level genome assembly for the rabbit tapeworm Taenia pisiformis

文献类型： 外文期刊

第一作者： Pu, Lixia

作者： Pu, Lixia;Liu, Zhongli;Guo, Aijiang;Zhang, Shaohua;Guo, Xiaola;Li, Xiaolu;Cai, Xuepeng;Wang, Shuai;Wu, Bin;Jian, Jianbo;Liu, Guo-hua;Wang, Shuai

作者机构：

关键词： Tapeworm; Taenia pisiformis; Genome; Evolution

期刊名称：GENE （ 影响因子：3.913； 五年影响因子：3.48 ）

ISSN： 0378-1119

年卷期： 2022 年 834 卷

页码：

收录情况： SCI

摘要： Taenia pisiformis is one of the most widespread gastrointestinal parasites and its larvae (cysticercosis) causes significant economic loss to rabbit industry. No efficient drug is available for this disease to date. To better understand its genomics, we assembled a 211-Mb high quality genome of T. pisiformis at chromosome level with a scaffold N50 size of 20 Mbp. Totally, 12,097 protein-coding genes was predicted from the genome. Genome-level phylogenetic analysis confirmed the taxonomic affiliations with other tapeworms and revealed that T. pisiformis diverged from its closely related relative T. hydatigena - 14.6 Mya. Comparative genomic analyses revealed that the T. pisiformis genome was characterized by adaptive features of strong positive selection signals from carbohydrate/lipid metabolism and body surface integrity, and of expanded gene families related to metabolism of amino acids and lipids. The high-quality genome of T. pisiformis constitutes a resource for the comparative genomics and for further applications in general parasitology.

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