Separation and Enrichment of β-Agonists from Animal Livers Based on Magnetic Solid-Phase Extraction with Automated-treatment Device

文献类型： 外文期刊

第一作者： Wei, Shu-Lin

作者： Wei, Shu-Lin;Wang, Zi-Hao;Li, Tong;Wang, Rui-Guo;Zhu, Huai-En;Shan, Ji-Hao;Song, Zhi-Chao

作者机构：

关键词： Magnetic solid-phase extraction; Automatic pretreatment; a-Agonist; Liver; Mass spectrometry

期刊名称：CHINESE JOURNAL OF ANALYTICAL CHEMISTRY （ 影响因子：1.2； 五年影响因子：1.0 ）

ISSN： 0253-3820

年卷期： 2024 年 52 卷 2 期

页码：

收录情况： SCI

摘要： A liquid chromatography -tandem mass spectrometry (LC-MS/MS) method was developed for determination of three kinds of f-agonists (Clenbuterol (CL), Ractopamine(RAC) and Salbutamol(SAL)) residues in animal liver samples. The liver sample homogenates were extracted with organic solvent, followed by clean-up using the automatic magnetic solid -phase extraction (MSPE), and then analyzed using LC-MS/MS. The results showed that the magnetic mixed -mode cation exchange adsorbent (M-MCX) exhibited 34% higher adsorption capacity than the conventional mixed -mode cation exchange (MCX) column. Furthermore, the clean-up was conducted by using an automatic MSPE device, and 8 samples could be simultaneously treated within 30 min. The limits of detection (LOD) were 0.01-0.1 mu g/kg, the average recoveries ranged from 88.2% to 110.5%, and the relative standard deviations (RSDs) were in range of 2.9%-10.3% at three spiked levels for the three kinds of 13-agonists. Compared with the traditional SPE technique, the present method had many advantages such as simple operation, rapidity and high efficiency, which was suitable for high -throughput and automatic detection of residues in routine analysis.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序