Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation

文献类型： 外文期刊

第一作者： Hong, Linjun

作者： Hong, Linjun;Zang, Xupeng;Hu, Qun;He, Yanjuan;Xu, Zhiqian;Xie, Yanshe;Gu, Ting;Yang, Huaqiang;Yang, Jie;Shi, Junsong;Zheng, Enqin;Huang, Sixiu;Xu, Zheng;Liu, Dewu;Cai, Gengyuan;Li, Zicong;Wu, Zhenfang;Hong, Linjun;Zang, Xupeng;Hu, Qun;He, Yanjuan;Xu, Zhiqian;Xie, Yanshe;Gu, Ting;Yang, Huaqiang;Yang, Jie;Zheng, Enqin;Huang, Sixiu;Xu, Zheng;Liu, Dewu;Cai, Gengyuan;Li, Zicong;Wu, Zhenfang;Hong, Linjun;Zang, Xupeng;Hu, Qun;He, Yanjuan;Xu, Zhiqian;Xie, Yanshe;Gu, Ting;Yang, Huaqiang;Yang, Jie;Zheng, Enqin;Huang, Sixiu;Xu, Zheng;Liu, Dewu;Cai, Gengyuan;Li, Zicong;Wu, Zhenfang;Shi, Junsong;Li, Zicong;Wu, Zhenfang

作者机构：

关键词： Uterine luminal fluid; Extracellular vesicles; Nanomedicine materials; Implantation; MEP1B

期刊名称：JOURNAL OF NANOBIOTECHNOLOGY （ 影响因子：10.2； 五年影响因子：11.5 ）

ISSN：

年卷期： 2023 年 21 卷 1 期

页码：

收录情况： SCI

摘要： Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are considered potential endogenous nanomedicines because of their unique biological functions. However, the limited supply of ULF-EVs prevents their development and application in infertility diseases such as implantation failure. In this study, pigs were used as a human biomedical model, and ULF-EVs were isolated from the uterine luminal. We comprehensively characterized the proteins enriched in ULF-EVs and revealed their biological functions in promoting embryo implantation. By exogenously supplying ULF-EVs, we demonstrated that ULF-EVs improve embryo implantation, suggesting that ULF-EVs are a potential nanomaterial to treat implantation failure. Furthermore, we identified that MEP1B is important in improving embryo implantation by promoting trophoblast cell proliferation and migration. These results indicated that ULF-EVs can be a potential nanomaterial to improve embryo implantation.

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