Rational design of nanocarriers for mitochondria-targeted drug delivery

文献类型： 外文期刊

第一作者： Huang, Lihua

作者： Huang, Lihua;Sun, Zonghao;Shen, Qian;Huang, Zhongxi;Wang, Shuangxi;Yang, Naidi;Li, Gongqiang;Wu, Qiong;Li, Lin;Yu, Changmin;Huang, Lihua;Sun, Zonghao;Shen, Qian;Huang, Zhongxi;Wang, Shuangxi;Yang, Naidi;Li, Gongqiang;Wu, Qiong;Li, Lin;Yu, Changmin;Wang, Wei;Yu, Changmin

作者机构：

关键词： Mitochondria target; Mitochondria diseases; Therapeutic drugs; Nanocarriers

期刊名称：CHINESE CHEMICAL LETTERS （ 影响因子：8.455； 五年影响因子：5.935 ）

ISSN： 1001-8417

年卷期： 2022 年 33 卷 9 期

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收录情况： SCI

摘要： Well-developed mitochondria-targeted nanocarriers for function regulation are highly desirable. Numerous studies have been conducted on the treatment of mitochondria-related diseases; however, further improvements are required to develop more effective drug delivery methods. Herein, we comprehensively introduce recent developments progress in rational design of mitochondria-targeted nanocarriers, and discuss the different strategies of available nanocarriers for targeting mitochondria. We also highlight the advantages and disadvantages of various carrier systems that are currently in use. Finally, perspective on new generation for mitochondria-targeted delivery systems in the emerging area of drug-based therapeutics is also discussed. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

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